ChemInform Abstract: A NEW SYNTHESIS OF 3‐HYDROXY‐3′‐4′‐METHYLENEDIOXYFLAVONE

Abstract

Aus o‐Hydroxyacetophenon wird mit Piperonal das Chalcon (I) erhalten, das in Gegenwart von H2O2 und Alkali zu (IIa) cyclisiert und oxidiert wird.

Modified Algar–Flynn–Oyamada Reaction for the Synthesis of 3-Hydroxy-2-styryl-chromen-4-ones under Solvent-Free Conditions

“…Keeping in view the significant biological properties and scarcity of 2-styrylchromones [4], the artificial synthesis of 3-hydroxy-2-styrylchromones has been considered. Few reports have been published for the synthesis of 3-hydroxy-2-styrylchromones via the Algar-Flynn-Oyamada reaction using hydrogen peroxide in an alkaline medium using H 2 O 2 -NaOH/EtOH, H 2 O 2 -KOH/MeOH, H 2 O 2 -NaOH/THF-MeOH, H 2 O 2 -NEt 2 /DMSO:1,4-dioxane as oxidizing agents [27][28][29][30][31][32][33][34].…”