ChemInform Abstract: A Practical Regioselective Synthesis of Alkylthio‐ or Arylthioindoles Without the Use of Smelly Compounds such as Thiols.

Abstract

A Practical Regioselective Synthesis of Alkylthio-or Arylthioindoles Without the Use of Smelly Compounds such as Thiols. -A series of 3-alkylthio-and 3-arylthioindoles is prepared by treatment of indoles with sulfoxides and TFAA followed by dealkylation of resulting sulfonium perchlorates in refluxing dipropylamine. -(HAMASHIMA, T.; MORI, Y.; SAWADA, K.; KASAHARA, Y.; MURAYAMA, D.; KAMEI, Y.; OKUNO, H.; YOKOYAMA, Y.; SUZUKI*, H.; Chem. Pharm. Bull. 61 (2013) 3, 292-303, http://dx.doi.org/10.1248/cpb.c12-00882 ; Fac. Pharm. Sci., Toho Univ., Funabashi, Chiba 274, Japan; Eng.) -R. Staver 33-129