ChemInform Abstract: A Safe and Reliable Procedure for the Iododeamination of Aromatic and Heteroaromatic Amines in a Continuous Flow Reactor.

Abstract

. -The copper-free iododeamination using the flow technique significantly improves the yield over the corresponding batch procedures. A wide range of substrates is subjected to these conditions affording the products (II) in moderate to good yields. The most common by-product is the diaryl-diazene. Substrates (I) possessing an electron-withdrawing group in para-, meta-, or ortho-positions, all provide reasonable yields, even in the case of the sterically hindered anilines, e.g. (