ChemInform Abstract: A Simple and Convenient Route to 1,2,3,4,5,6,7,8‐Octahydro‐1,6‐naphthyridines.

Abstract

A Simple and Convenient Route to 1,2,3,4,5,6,7,8-Octahydro-1,6naphthyridines.-Lithiation of 4-piperidinoimines (I) and subsequent quenching with 1,3-bromochloropropane (II) results in a simple one-pot synthesis of the title compounds (III), required as synthons of biologically active compounds. -(GAIDAROVA, E. L.; BORISENKO, A. A.; CHUMAKOV, T. I.; MEL'NIKOV, A. V.; ORLOV, I. S.; GRISHINA, G. V.; Tetrahedron Lett. 39 (1998) 42, 7767-7770; Dep. Chem., Lomonosov Moscow State Univ., Moscow 119899, Russia; EN)