ChemInform Abstract: A Total Synthesis of (.+‐.)‐Tirandamycin B.

Abstract

A Total Synthesis of (±)-Tirandamycin B.-The key steps are cyclization of the pyranone (II), reductive removal of the benzyl protecting group from the enone (III) and condensation of the phosphonate (VII) with the aldehyde (VI). -(SHIMSHOCK, S. J.; WALTERMIRE, R. E.; DESHONG, P.; J. Am. Chem. Soc. 113 (1991) 23, 8791-8796; Dep. Chem. Biochem., Univ. Md.,