ChemInform Abstract: Ajugins C (I) and D (II), New Withanolides from Ajuga parviflora

Khan, Pir Muhammad; Nawaz, Hafiz Rub; Ahmad, Saeed; Malik, Abdul

doi:10.1002/chin.200002208

Cited by 1 publication

(1 citation statement)

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“…[60][61] Two new withanolides, ajugin C (=(20R,22R)-4β,14α,20,27tetrahydroxy-1-oxoergosta-2,5,24-trieno-26,22-lactone and ajugin D (=(20R,22R)-8β,14α,17β,20,27-pentahydroxy-1oxoergosta-5,24-dieno-26,22-lactone, were isolated from the whole plant of A. parviflora. [62] Two withanolides, 20β-hydroxy-1-oxo-(22R)-witha-2,5,24-trienolide and withacoagulin, along with a known withanolide, 17β-hydroxy-14α,20α-epoxy-1-oxo-(22R)-witha-3,5,24-trienolide were isolated from W. coagulans. [63] Minor new withanolides, daturametelins C, D, E, F, and G-Ac, were isolated from the methanolic extract of the fresh aerial parts of D. metel.…”

Section: Angiogenesis Inhibitormentioning

confidence: 99%

Withanolides: Phytoconstituents with significant pharmacological activities

Singh¹,

Duggal²,

Singh³

et al. 2010

Int J Green Pharm

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Withanolides are a group of naturally occurring oxygenated ergostane type steroids, having lactone in side chain and 2-en-1-one system in the ring. Withanolides are present in medicinal plants of Solanaceae family. Formulations based on these medicinal plants are widely used in Ayurveda and traditional Chinese medicine. Withanolides have shown a wide range of pharmacological activities including hypno¬sedative, immunomodulatory, anti-inflammatory, antiarthritic, angiogenesis inhibitor, anticholinesterase, antioxidant, antibacterial and above all, antitumour. Withaferin A is the best studied withanolide as far as pharmacological investigations are concerned. The present review summarises the investigative work carried out on bioactive withanolides.

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