ChemInform Abstract: An Expeditious Method for the Preparation of 2‐Hydroxy‐1,4‐dioxane and Its Use in Reductive Alkylation of Amines.

Abstract

. -Title compound (I) is found to be a useful aldehyde for the reductive alkylation of amines to give (2-hydroxyethoxy)amines in varying yields. The hydroxydioxane itself is prepared by careful Ru-catalyzed monooxidation of diethylene glycol with sodium periodate and isolated as dichloromethane solution. -(VINTER*, A.; AVDAGIC, A.; STIMAC, V.; PALEJ, I.; CIKOS, A.; SUNJIC, V.; ALIHODZIC, S.; Synthesis 2010, 2, 255-258; GlaxoSmithKline Res.