ChemInform Abstract: An Extremely Short Synthesis of the Prostaglandin Key Intermediate Through a Novel Vinyl Anion Equivalent.

Abstract

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

The Untold Journey of Total Synthesis of Natural Products

“…3 The preparation of the α-acylcyclopentenone derivative was unexpectedly the major challenge, since the originally planned Morita–Baylis–Hillman did not work and the modified synthesis using Nozaki–Hiyama–Kishi coupling could not be well reproduced by the year-one postgraduate student. Literature survey suggested that Toru’s method (PhSeCl, Bu 3 SnSnBu 3 / n -BuLi) 4 might be applicable to the preparation of the α-acylcyclopentenone derivative. However, use of the tin reagent became a big safety concern for the inexperienced student who was working on this project and reported to me that Toru’s method did not work.…”