ChemInform Abstract: ANTIDEPRESSANT AGENTS PART 1, CHEMISTRY AND PHARMACOLOGY OF AMINO‐SUBSTITUTED SPIRO(5H‐DIBENZO(A,D)CYCLOHEPTENE‐5,1′‐CYCLOALKANES)

Abstract

Aus den Dibenzo‐cycloheptanon‐Derivaten (Ia)‐(Id) entstehen mit der Grignard= Verbindung (II) die Addukte (III), aus denen mit Ameisensäure die Aldehyde (IV) gebildet werden.

Inhibitors of neuronal monoamine uptake. 2. Selective inhibition of 5-hydroxytryptamine uptake by .alpha.-amino acid esters of phenethyl alcohols

“…The aromatic substituents are also of importance for the potency and to some extent for the selectivity. Thus, compounds with a chlorine atom at the 4 or 3 position (1,4) were more selective for the 5-HT accumulation than the compound with a 2-chlorine (5) or without any aromatic substituent (9). A 4-bromo (7) or 4-methyl (10) substituent was equivalent to a chlorine atom, whereas a 4-methoxy group (12) decreased the activity.…”