ChemInform Abstract: Aquasomes: A Novel Drug Carrier System

Vengala, Pavani; Shwetha, Dintakurthi; Kumaraswamy, Pabbapi

doi:10.1002/chin.201322246

Cited by 4 publications

(4 citation statements)

References 21 publications

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“…The bag is then placed with 300 ml buffer and media must be stirred at a speed of 100 rpm at 37±0.5 o C. Aliquots of 5ml samples are withdrawn at various time intervals and analysed for the drug content at a specific wavelength using a UV spectrophotometer. Sink condition is to be maintained with 5 ml of fresh dissolution medium (7,43) .…”

Section: H// In Vitro Drug Release Studiesmentioning

confidence: 99%

“…Nanoparticles can be broadly classified as organic and inorganic nanoparticles. Organic particles can contain carbon nanoparticles (fullerenes) while magnetic nanoparticles, fine metal nanoparticles (such as gold and silver) and semiconductor nanoparticles (such as titanium dioxide and zinc oxide) are the inorganic ones (6,7) . The inorganic nanoparticles have grabbed more attention due to numerous characteristics such as high availability, better compatibility, rich functionality and their ability for site-specific drug delivery in a controlled manner (8) .…”

Section: Introductionmentioning

confidence: 99%

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Aquasomal drug delivery system: A special emphasis on the formulation techniques and applications

Rajak,

Islam,

Karmakar

et al. 2023

Ars Pharm

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Introduction: Aquasome is a self-assembled nanoparticulate carrier system with three layers. The system is made up of a polyhydroxy oligomer-coated inner nanocrystalline solid core. Adsorbed on the coated layer are drug molecules or biochemically active compounds. Self-assembly in this sense refers to the independent formation of molecules into organised, long-lasting, and non-covalently bonded patterns.This paper gives an overview of aquasome formation, covering structural properties, formulation methodologies, and the benefits and drawbacks of this novel drug delivery technology. The article primarily addresses the formulation processes used to create self-assembled nanostructures and their various possible applications. Method: Several online databases, including Science Direct, Medline, Web of Science, Google Scholar and Scopus, were used in the literature search. The datasets were searched for entries of studies up to July, 2023. The review paper especially addresses many elements of aquasome formation by various researchers employing methods/modified techniques such as co-precipitation, self-precipitation, sputtering, and and so forth. It also illustrates a variety of fields of therapy in which aquasome has been recognised to have a major influence, such as oxygen and extract carrier. Results: The solid core is responsible for providing structural stability, while the oligomeric coating is crucial for safeguarding against dehydration and stabilising the bioactive molecules. This biodegradable drug delivery vehicle at the nanoscale level exhibits a tendency to accumulate in the liver and muscles. The non-modification of drug adsorption onto the aquasome surface facilitates prompt pharmacological response by allowing unobstructed receptor recognition at the action site. Conclusions: Aquasome, a three-layered self-assembled molecule, is a simple yet new drug delivery system with promising carrier potentials to increase the solubility and bioavailability of poorly soluble drugs. Despite a host of challenges, such as time consumption, sophisticated processes, safety, and expensive research costs, aquasome may emerge as an alternative vesicular carrier in the future.

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Section: H// In Vitro Drug Release Studiesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Aquasomal drug delivery system: A special emphasis on the formulation techniques and applications

Rajak,

Islam,

Karmakar

et al. 2023

Ars Pharm

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“…APPLICATIONS [32][33][34][35][36] 1. Viruses such as the Epstein-Barr Virus and the Human Immunodeficiency Virus are transmitted using aquasomes as vaccines.…”

Section: Materials Used and Its Importance [28]mentioning

confidence: 99%

Aquasomes Nanocarriers for Delivery of Small Molecules

Kallingal¹,

Suresh²

2021

IJMPS

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Aquasomes are nanobiopharmaceutical carrier devices having a polyhydroxyl oligomeric layer surrounding them and a nanocrystalline calcium phosphate or ceramic diamond particle core. Aquasomes are spherical spheres with a diameter of 60-300 nanometers that are used to deliver medications and antigens. Because of qualities such as protection and preservation of delicate biological molecules, conformational integrity, and surface exposure, it was an excellent carrier mechanism delivering bioactive molecules such as peptides, proteins, hormones, antigens, and genes to specific sites. The most common core materials used to manufacture aquasomes are tin oxide, nanocrystalline carbon ceramics (diamonds), and brushite (calcium phosphate dihydrate). Calcium phosphate is the focus of attention due to its natural function in the body. Brushite is an acidic mineral that converts into hydroxyapatite after being stored for a long time. As a consequence, hydroxyapatite seems to be a more powerful centre for aquasome preparation. It’s often used in the design of drug-delivery implants. A putative artificial oxygen-carrying mechanism has been found as hemoglobin-loaded aquasomes with a hydroxyapatite core. Because of their structural integrity, aquasomes have been employed as red blood cell substitutes, vaccines for delivering viral antigen (Epstein-Barr Virus and Human Immunodeficiency Virus) to elicit appropriate antibodies, and a targeted technique for intracellular gene therapy. Due to their enzyme activity and responsiveness to molecular conformation, aquasomes were created as a new carrier for enzymes such as DNAses and pigment/dyes. The challenges of retaining the conformational integrity and biochemical functioning of immobilised surface pairs, as well as the integration of these principles into a single functional composition, are described in this article.

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“…3. Aquasomes have been used for successful targeted intracellular gene therapy 29,30 , a five layered composition comprised of ceramic core, polyoxyoligomeric film, therapeutic gene segment, additional carbohydrate film and a targeting layer of conformationally conserved viral membrane protein.…”

Section: Applicationsmentioning

confidence: 99%

Aquasomes: A Nanoparticulate Drug Carrier System

S¹,

Jagadeeswari.²,

Padmalatha³

2018

AJPTR

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Nanotechnology has emerged fields of biomedical research in the last few decades the presents context is an attempt to present the brief information about nanobiotechnological applications.Aquasomes are one of the most recently developed delivery system for bioactive molecules like peptide, protein, hormones, antigens and genes to specific sites. Aquasomes are spherical in shape with 60-300 nm particles size. Aquasomes are nanoparticulate carrier system but instead of being simple nanoparticles these are three layered self assembled structures, comprised of a solid core coated with oligomeric film to which biochemically active molecules are adsorbed with or without modification. These structures are self assembled by non covalent and ionic bonds. The solid core provides the structural stability, while the carbohydrate coating protects against dehydration and stabilizes the biochemically active molecules. This article reviews the principles of self assembly, strategies used in chemical synthesis, methods of preparation, characterization and application of Aquasomes.

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ChemInform Abstract: Aquasomes: A Novel Drug Carrier System

Cited by 4 publications

References 21 publications

Aquasomal drug delivery system: A special emphasis on the formulation techniques and applications

Aquasomal drug delivery system: A special emphasis on the formulation techniques and applications

Aquasomes Nanocarriers for Delivery of Small Molecules

Aquasomes: A Nanoparticulate Drug Carrier System

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