ChemInform Abstract: Bismuth Heterocycles Based on a Diphenyl Sulfone Scaffold: Synthesis and Substituent Effect on the Antifungal Activity Against Saccharomyces cerevisiae.

Abstract

Bismuth Heterocycles Based on a Diphenyl Sulfone Scaffold: Synthesis and Substituent Effect on the Antifungal Activity Against Saccharomyces cerevisiae. -A variety of heterocyclic organo-bismuth(III) compounds are synthesized and evaluated for their antifungal activity. Compounds (IIIa), (IIId), and (Vb) are the most active against S. cerevisiae. The results of the antifungal assay are correlated with the lipophilicity of the tested substances. -(MURAFUJI*, T.; FUJIWARA, Y.; YOSHIMATSU, D.; MIYAKAWA, I.; MIGITA, K.; MIKATA, Y.; Eur. J. Med. Chem. 46 (2011) 2, 519-525, http://dx.doi.org/10.1016/j.ejmech.2010.11.031 ; Grad. Sch. Med., Yamaguchi Women's Univ., Yamaguchi 753, Japan; Eng.) -H. Haber 23-169