ChemInform Abstract: Catalytic Asymmetric Hydrogenation of α‐Amino‐β‐keto Ester Hydrochlorides Using Homogeneous Chiral Nickel‐Bisphosphine Complexes Through DKR.

Abstract

Hydrogenation O 0220Catalytic Asymmetric Hydrogenation of α-Amino-β-keto Ester Hydrochlorides Using Homogeneous Chiral Nickel-Bisphosphine Complexes Through DKR. -The asymmetric hydrogenation using homogeneous chiral Nickel-bisphosphine complexes is superior to the iridium-catalyzed process regarding the substrate generality and enantioselectivity. -(HAMADA*, Y.; KOSEKI, Y.; FUJII, T.; MAEDA, T.; HIBINO, T.; MAKINO, K.; Chem. Commun. (Cambridge) 2008, 46, 6206-6208; Grad. Sch. Pharm. Sci., Chiba Univ., Inage, Chiba 263, Japan; Eng.) -M. Paetzel