ChemInform Abstract: Cation‐Directed Enantioselective N‐Functionalization of Pyrroles.

Armstrong, Roly J.; D’Ascenzio, Melissa; Smith, Martin D.

doi:10.1002/chin.201623182

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“…Furthermore, we would be remiss not to mention other efficient methods that have been successfully developed for the synthesis of chiral aminals. These include Toste's fluorination-initiated asymmetric cyclization, 27 Smith's asymmetric phase-transfer catalysis, 28 and Zhou's Brønsted acid catalyzed (R-TRIP) synthesis. 29 Each of these approaches contributes uniquely to the diverse toolkit available for the preparation of chiral aminals, highlighting the richness of methodologies in contemporary asymmetric synthesis.…”

Section: Scheme 9 List's Cpa-catalyzed Enantioselective Synthesis Of ...mentioning

confidence: 99%

Progress on the Synthesis and Applications of Aminals: Scaffolds for Molecular Diversity

Rippel,

Ferreira,

Branco

2024

Synthesis

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Aminals, characterized by a central carbon linking two nitrogen atoms, are versatile building blocks in modern chemistry. This review addresses a literature gap by exploring the synthesis and applications of aminals, with a focus on drug discovery and molecular diversity. Beyond medicinal chemistry, aminals find applications as key components in bioactive compounds and versatile tools in materials chemistry. The review covers fundamental characteristics, synthetic methodologies, stability, and applications, emphasizing alternative synthesis methods to the well-established aldehyde-amine condensation. This inclusive exploration provides insights into diverse synthetic pathways, expanding the versatility of the aminal scaffold. 1. Introduction 2. The Aminal Group 3. Aminal Synthesis 3.1 Metal-free Approaches 3.2 Metal-catalyzed Approaches 3.3 Photoredox Methodologies 3.4 Via rearrangements 3.5 Decarboxylative Coupling 4. Aminals as Synthetic Tools 5. Synthesis of Aminal-containing Natural Products 6. Aminal-based Materials 7. Conclusions

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Section: Scheme 9 List's Cpa-catalyzed Enantioselective Synthesis Of ...mentioning

confidence: 99%

Progress on the Synthesis and Applications of Aminals: Scaffolds for Molecular Diversity

Rippel,

Ferreira,

Branco

2024

Synthesis

View full text Add to dashboard Cite

show abstract

ChemInform Abstract: Cation‐Directed Enantioselective N‐Functionalization of Pyrroles.

Abstract: Cation-Directed Enantioselective N-Functionalization of Pyrroles. -(ARMSTRONG, R. J.; D'ASCENZIO, M.; SMITH*, M. D.; Synlett 27 (2016) 01, 6-10, http://dx.doi.org/10.1055/s-0035-1560813 ; Chem. Res. Lab., Univ. Oxford, Oxford OX1 3TA, UK; Eng.) -D. Homolka 23-182

Cited by 1 publication

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Progress on the Synthesis and Applications of Aminals: Scaffolds for Molecular Diversity

Progress on the Synthesis and Applications of Aminals: Scaffolds for Molecular Diversity

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