ChemInform Abstract: Chemotherapeutic Agents. Part 11. Synthesis of Pyrimidines and Azolopyrimidines as Leishmanicides.

Abstract

The title pyrimidines, e.g. (I), (III), (V), (VII) and (IX), and a variety of azolopyrimidines, synthesized from (V), are tested in vivo as leishmanicidal agents.

Synthesis, Spectral Studies, and Theoretical Treatment of New Ni(II),and Co(II) Complexes of Bidenetate Ligands 2-Benzamido Benzothiazole ,and 2-Actamido Benzothiazole

“…The program Hyper chem-8 was used for semi -empirical molecular mechanic calculation .The heat of formation ∆H˚f, binding energy(∆E b )and dipole moment (µ) for free ligands and complexes were calculated by PM3,and ZINDO/1 methods, Tables (4), and(5). Also PM3 was used for evaluating the vibrations of new ligands (B1 and B2), Table (6 As shown in Tables4 and 5, the binding energy and energy required for formation of the compounds can be arranged as follows:…”

“…The result of PM3 method of calculations in gas phase for the heat of formation ,binding energy ,and dipole moment of new benzothiazole derivatives were tabulated in Tables (4), and(5). The vibration spectra of free ligands have been calculated, as shown in Table (…”

Synthesis of Novel Benzothiazolo[3,2‐a]pyridimidin‐4‐ones with Potential Cytotoxic and Pro‐Apoptotic Potential

“…Among the many different series of benzothiazoles, benzothiazolo[3,2 ‐ a ]pyrimidin ‐ 4 ‐ ones are important heterocyclic core structures with tremendous pharmacological potential. These derivatives are reported for their anti‐leishmanial, sedative, antifungal, and antibacterial properties . However, only a few synthetic strategies for the synthesis and functionalization of these heterocyclic scaffolds have been reported to date .…”