ChemInform Abstract: Chiral Pool Synthesis of N‐Cbz‐cis‐(3R,4R)‐3‐methylamino‐4‐methylpiperidine from L‐Malic Acids.

Abstract

Title compound (II), key building block for the synthesis of the first‐in‐class Janas tyrosine kinase inhibitor CP‐690,550, is prepared from cheap raw materials using established transformations.