ChemInform Abstract: Concise Synthesis of 6‐Cyanobenzo[b]furan, a Useful Building Block.

Abstract

Concise Synthesis of 6-Cyanobenzo[b]furan, a Useful Building Block. -The described synthesis starts from the commercially available furan-3-one derivative (I) which undergoes a reductive dehydration and conversion to a triflate derivative. The title compound (VI) is finally obtained after conversion of the triflate with zinc cyanide, using a palladium-catalyzed cyanation protocol. -(NGUYEN, S. T.; WILLIAMS, J. D.; MAJGIER-BARANOWSKA, H.; LI, B.; NEELAGIRI, V. R.; KIM, H.-O.; PEET*, N. P.; Synth. Commun. 44 (2014) 9, 1307-1313, http://dx.