ChemInform Abstract: Construction of Functionalized Spiro 1,4‐Benzoxazine Oxindole Derivatives via Domino Mannich‐Alkylation of α‐Halocarbonyl Compounds with Imines.

Abstract

Construction of Functionalized Spiro 1,4-Benzoxazine Oxindole Derivatives via Domino Mannich-Alkylation of α-Halocarbonyl Compounds with Imines. -The reaction proceeds under mild conditions and allows the preparation of the title compounds on a gram scale. In general, the products are obtained with excellent diastereoselectivity. -(HUANG, X.; ZHANG, Y.-R.; LI, X.-S.; XU, D.-C.; XIE*, J.-W.; Tetrahedron Lett. 54 (2013) 44, 5857-5860, http://dx.