ChemInform Abstract: Current Biological and Synthetic Profile of Triazoles

Abstract

Review: 16 refs.

Design, synthesis, and antifungal activities of novel triazole derivatives containing the benzyl group

“…3 , 4 Azole nitrogen compounds have been progressively getting people’s attention, mainly because of their superiority in antifungal therapy but also for their contribution in the treatment of various microbes. 5 Azoles (fluconazole, itraconazole, voriconazole, and posaconazole, Figure 1 ) are one very significant class of compounds for treating deep fungal infections in the clinical context. 6 One of the principal problems in the treatment of Candida albicans infections is the spread of antifungal drug resistance, mainly in patients chronically subjected to antimycotic therapy such as HIV-infected people.…”

Sustainable electrocatalytic oxidation of N-alkylamides to acyclic imides using H2O

“…Extensive research on 1,2,4-triazoles by Pattan et al has revealed their antibacterial, antifungal, antitubercular, and anti-inflammatory activities. 31 Notably, many FDA-approved drug molecules, such as itraconazole, fluconazole, and voriconazole, contain the 1,2,4-triazole scaffold, further highlighting its significance in medicinal applications. By utilizing imide 2b and phenylhydrazine, for instance, a remarkable 96% yield of 1,5-diphenyl-1 H -1,2,4-triazole 3 can be obtained, showcasing the potential of imides as precursors for the synthesis of biologically relevant 1,2,4-triazole compounds.…”

Synthesis of Some New 4-methylpiperazin-1-yl-methyl-4H-1,2,4-triazole-3- thiol Derivatives of Expected Anticancer and Antimicrobial Activity

“…Some of these activities include antibacterial, antifungal, antitumor, anti-inflammatory, antitubercular, hypoglycemic, antidepressant, anticonvulsant, analgesic, antiviral, anticancer, antimalarial, antioxidant etc. [34][35][36][37]. The application of 1,2,4-triazoles in the development of new molecules has seen a remarkable development over the period of recent history.…”