ChemInform Abstract: Cyclohexylethanoids from the Flower of Campsis grandiflora

Kim, Dong‐Hyun; Bang, Myun‐Ho; Lee, Youn‐Hyung; Chung, In‐Sik; Kim, Dae‐Keun; Kim, Sung‐Hoon; Kwon, Byoung‐Mog; Park, Mi‐Hyun; Baek, Nam-In

doi:10.1002/chin.200810219

Cited by 2 publications

(2 citation statements)

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“…The signal at 104.2 ppm is attributed to the anomeric carbon of glucose ( Figure 5 C). Collectively, these data indicate the presence of a glycosylated ethylcyclohexanoid, as the molecule cornoside [ 47 , 48 ]. The HSQC analysis could confirm the correlation between hydrogens H-3/H-5 (δ = 7.02 ppm) and H-2/H-6 (δ = 6,12 ppm) and carbons C-3/C-5 (δ = 154,5) and C-2/C-6 (δ = 154.5 ppm), respectively ( Figure 5 D).…”

Section: Resultsmentioning

confidence: 99%

Hypoglycemic Activity of Aqueous Extract of Latex from Hancornia speciosa Gomes: A Study in Zebrafish and In Silico

et al. 2021

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Hancornia speciosa Gomes is a tree native to Brazil and has therapeutic potential for several diseases. Ethnopharmacological surveys have reported that the plant is used as a hypoglycemic agent and to lose weight. This study aimed to evaluate the effects of the aqueous extract from H. speciosa latex (LxHs) in a zebrafish model of diabetes. The extract was evaluated through high-performance thin-layer chromatography (HTPLC), nuclear magnetic resonance (NMR), and Fourier-transform infrared spectroscopy (FT-IR). We then tested treatments with LxHs (500, 1000, and 1500 mg/kg) by assessing blood glucose levels in alloxan-induced diabetic animals, and metformin was used as a control. The toxicity was evaluated through histopathology of the pancreas and biochemical assessment of serum levels of AST, ALT, creatinine, and urea. The extract was also assessed for acute toxicity through several parameters in embryos and adult animals. Finally, we performed in silico analysis through the SEA server and docking using the software GOLD. The phytochemical study showed the compounds cornoside, dihydrocornoide, and 1-O-methyl-myoinositol (bornesitol). The treatment with all doses of LxHs significantly decreased alloxan-induced hyperglycemia without any significant histological or biochemical abnormalities. No significant frequency of teratogenesis was observed in the embryos exposed to the extract, and no significant behavioral changes or deaths were observed in adult animals. In silico, the results showed a potential interaction between inositol and enzymes involved in carbohydrates’ metabolism. Overall, the results show a hypoglycemic activity of the extract in vivo, with no apparent toxicity. The computational studies suggest this could be at least partially due to the presence of bornesitol, since inositols can interact with carbohydrates’ enzymes.

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Section: Resultsmentioning

confidence: 99%

Hypoglycemic Activity of Aqueous Extract of Latex from Hancornia speciosa Gomes: A Study in Zebrafish and In Silico

et al. 2021

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“…Several chemical constituents including flavonoids, iridoids, triterpenoids, and phenolic acid derivatives have been identified in the flower of C. grandiflora. [1][2][3][4][5][6] Stagnant blood (oketsu in Japanese), considered as a severe important pathological condition in traditional Chinese and Japanese medicine, is one of the leading causes of gynecopathy, poor circulation, and shoulder discomfort. Development of novel drugs to treat oketsu can improve the quality of life of many people suffering from these symptoms.…”

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Effect of the Dried Flowers of Campsis grandiflora on Stagnant Blood Syndrome

Oku

Iwaoka

Shinga

et al. 2019

Natural Product Communications

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Dried flower of Campsis grandiflora (Bignoniaceae), known as ryoushouka in Japanese, is a traditional Chinese medicine used to treat stagnant blood, contusion, pruritus, and gynecopathy such as menstrual and menopausal disorders. In the present study, we evaluated the stagnant blood flow (BF) improvement effect of the methanol extract (CG) of dried flowers of C. grandiflora using an in vivo assay, in a continuing effort to improve peripheral circulatory disturbance using natural sources. We used the assay system to monitor a decrease in BF in the tail vein microcirculation of mice subjected to sensitization with hen-egg white lysozyme. Bioassayguided fractionation of the CG led to the isolation of apigenin (1), acteoside (2), cleroindicin B (3), rengyol (4), and isorengyol (5). Apigenin (1) and acteoside (2) were identified as active compounds as they exhibited significant stagnant BF improvement effect in the peripheral circulation. This study proved the positive effect of ryoushouka against stagnant blood syndrome.

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ChemInform Abstract: Cyclohexylethanoids from the Flower of Campsis grandiflora

Cited by 2 publications

References 1 publication

Hypoglycemic Activity of Aqueous Extract of Latex from Hancornia speciosa Gomes: A Study in Zebrafish and In Silico

Hypoglycemic Activity of Aqueous Extract of Latex from Hancornia speciosa Gomes: A Study in Zebrafish and In Silico

Effect of the Dried Flowers of Campsis grandiflora on Stagnant Blood Syndrome

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