ChemInform Abstract: Design, Synthesis and Bioevaluation of Novel Candidate Selective Estrogen Receptor Modulators.

Abstract

Design, Synthesis and Bioevaluation of Novel Candidate Selective Estrogen Receptor Modulators. -The compounds (IV) and (VI) are evaluated against estrogen-responsive human MCF-7 breast cancer cells. The compounds (IV) show moderate activity, whereas the compounds (VI) show enhanced cytotoxicity against MCF-7 cells. -(YADAV, Y.; MACLEAN, E. D.; BHATTACHARYYA, A.; PARMAR, V. S.; BALZARINI, J.; BARDEN, C. J.; TOO, C. K. L.; JHA*, A.; Eur. J. Med. Chem. 46 (2011) 9, 3858-3866, http://dx.