1998
DOI: 10.1002/chin.199818280
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ChemInform Abstract: DNA Gyrase Inhibitory Activity of Ellagic Acid Derivatives.

Abstract: 1998 pharmacology, medicinal chemistry, vaccines, serums pharmacology, medicinal chemistry, vaccines, serums V 1100 18 -280 DNA Gyrase Inhibitory Activity of Ellagic Acid Derivatives. -Fluorenone (II) is found to be more potent in DNA gyrase inhibitory activity than parent compound ellagic acid. -(WEIDNER-WELLS, M. A.; ALTOM, J.; FERNANDEZ, J.; FRAGA-SPANO, S. A.; HILLIARD, J.; OHEMENG, K.; BARRETT,

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“…Since several naturally occurring polyphenols, such as ellagic acid and EGCG, are potent bacterial DNA gyrase inhibitors, [34,43] we decided to examine the inhibition activities of a group of polyphenols collected in our laboratory against E. coli DNA gyrase (Figure S1). As expected, ellagic acid, EGCG, and 3,5‐dicaffeoylquinic acid strongly inhibit E. coli DNA gyrase (Figures 1, S1, and S2).…”
Section: Resultsmentioning
confidence: 99%
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“…Since several naturally occurring polyphenols, such as ellagic acid and EGCG, are potent bacterial DNA gyrase inhibitors, [34,43] we decided to examine the inhibition activities of a group of polyphenols collected in our laboratory against E. coli DNA gyrase (Figure S1). As expected, ellagic acid, EGCG, and 3,5‐dicaffeoylquinic acid strongly inhibit E. coli DNA gyrase (Figures 1, S1, and S2).…”
Section: Resultsmentioning
confidence: 99%
“…Natural products, such as polyphenols, are rich sources to identify antibiotics or antibacterial agents [30–32] . For instance, ellagic acid, found in a large variety of foods including pecan, walnuts, cranberries, strawberries, and pomegranates, [33] is a potent bacterial DNA gyrase inhibitor [34] and has antibacterial activities [35,36] . Antibiotic novobiocin, produced by Streptomyces niveus , [37] is also a polyphenol [38] and has strong antibacterial activities especially against Gram‐positive bacteria [39] .…”
Section: Introductionmentioning
confidence: 99%