ChemInform Abstract: Efficient Syntheses of Fluorine‐Containing Pyrimido[5,4‐c]quinolines and Benzo[h][1,6]naphthyridines by Condensation Reactions of 3‐Trifluoroacetylquinolin‐4‐amine with Aldehydes and Ketones.

Abstract

Efficient Syntheses of Fluorine-Containing Pyrimido[5,4-c]quinolines and Benzo[h][1,6]naphthyridines by Condensation Reactions of 3-Trifluoroacetylquinolin-4-amine with Aldehydes andKetones. -3-Trifluoroacetyl-4-aminoquinoline (I) undergoes a three-component condensation reaction with aldehydes ammonia to afford pyrimidoquinoline derivatives as single or major products. Similar reaction of (I) with ketones gives benzonaphthyridine derivatives via a Friedlaender-type cyclization. -(OKADA*, E.; HATAKENAKA, M.; NAKANO, S.; SAKAEMURA, T.; MORI, T.; TERAUCHI, T.; Heterocycles 89 (2014) 10, 2303-2317, http://dx.