ChemInform Abstract: Facile and General Synthesis of 2‐, 3‐, or 4‐((Dialkylamino)alkyl) pyridines and ‐piperidines.

Abstract

Facile and General Synthesis of 2-, 3-, or 4-((Dialkylamino)alkyl) pyridines and -piperidines.-Alkylation of picolyllithiums with aminoalkyl chlorides (II) provides the corresponding aminoalkylpyridines (III) (8 examples) which can be efficiently hydrogenated furnishing the corresponding piperidines (IV) in high yields. -(COHEN, V. I.; JIN, B.; REBA, R. C.;