ChemInform Abstract: Fluorinated Amino Acids. Part 3. Synthesis of β‐Difluoromethyl‐m‐ tyrosine.

Abstract

Fluorinated Amino Acids. Part 3. Synthesis of β-Difluoromethyl-mtyrosine. -A synthesis of the chiral difluoromethyl carboxylic acid (X) has been developed to access the absolute configuration of a oxazole (XI) synthesized in the preceding paper. (XI) as well as its diastereomer are transferred into the corresponding β-difluoromethyl-m-tyrosine (cf. (XIII)). -(SABOL, J. S.; BRAKE, N. W.; MCDONALD, I. A.; Tetrahedron Lett. 35 (1994) 12, 1821-1824 Marion Merrell Dow Res. Inst., Cincinnati, OH 45215, USA; EN)