ChemInform Abstract: Gold‐Catalyzed Intermolecular [4C + 3C] Cycloaddition Reactions.

Abstract

Gold-Catalyzed Intermolecular [4C + 3C] CycloadditionReactions. -It is demonstrated that Au-catalysts are capable of initiating the reaction of alkynes (I) with cyclic dienes. The formation of the seven-membered rings occurs by a [4 + 3] cycloaddition, rather than a stepwise cyclopropanation/Cope rearrangement sequence. Cyclopropanes (IV) can be readily transformed to (III) by Cope rearrangement in toluene under reflux (12h). The seven-membered products represent a central core of the cortistatins.