ChemInform Abstract: Highly Stereoselective Approach to 3‐Fluoroalkylated (E)‐Hex‐3‐ene‐1,5‐diyne Derivatives via an Addition—Elimination Reaction.

Abstract

Highly Stereoselective Approach to 3-Fluoroalkylated (E)-Hex-3-ene-1,5-diyne Derivatives via an Addition-Elimination Reaction. -Five 1-fluoroalkylated 1-fluoroenyne compounds of type (III) are prepared. Addition-elimination reactions of these compounds with various alkynyllithium compounds yield diyne derivatives of type (V)/(VI) with excellent E-selectivity. -(KONNO*, T.; KISHI, M.; ISHIHARA, T.; YAMADA, S.; J. Fluorine Chem. 156 (2013) 144-151, http://dx.doi.org/10.1016/j.jfluchem.2013.09.010 ; Dep. Chem. Mater. Technol., Kyoto Inst. Technol., Sakyo, Kyoto 606, Japan; Eng.) -M. Bohle 18-063