ChemInform Abstract: Highly Stereoselective Methylene Transfers onto Butanediacetal‐Protected Chiral Non‐Racemic Sulfinyl Imines Using S‐Ylide Technology.

Abstract

Aziridine derivatives R 0040Highly Stereoselective Methylene Transfers onto Butanediacetal-Protected Chiral Non-Racemic Sulfinyl Imines Using S-Ylide Technology. -Diastereomeric ratios of >90% are achieved when performing the title reaction onto imines, e.g. (III), derived from D-mannitol and (S)-2-methyl-2-propane sulfinamide (II). The stereochemistry of the new aziridine stereocenter in products, e.g. (V) and (VII) is not established. -(FORBES*, D. C.; BETTIGERI, S. V.; PISCHEK, S. C.; Chem.