ChemInform Abstract: Imidazoles from Nitroallylic Acetates and α‐Bromonitroalkenes with Amidines: Synthesis and Trypanocidal Activity Studies.

Abstract

Imidazoles from Nitroallylic Acetates and -Bromonitroalkenes with Amidines: Synthesis and Trypanocidal Activity Studies. -Cascade reactions of amidines (II) with title compounds (I) and (IV) afford 2,4,5-trisubstituted and 2,4-disubstituted imidazoles (III), (V), and (VI), respectively. Some of the obtained compounds exhibit trypanocidal activity similar or even higher [cf. (IIIa)] than the standard benznidazole. -(GOPI, E.; KUMAR, T.; MENNA-BARRETO, R. F. S.; VALENCA, W. O.; DA SILVA*, E. N. J.; NAMBOOTHIRI, I. N. N.; Org. Biomol. Chem. 13 (2015) 38, 9862-9871, http://dx.