ChemInform Abstract: Improved Auxiliary for the Synthesis of Medium‐Sized Bis(lactams).

Abstract

Multi-membered N-heterocycles R 0690Improved Auxiliary for the Synthesis of Medium-Sized Bis(lactams). -The novel auxiliary (I) is incorporated into the backbone of linear peptides facilitating the reactive terminal groups to approach one another for intramolecular cyclization. Subsequent ring contraction furnishes medium-sized bis (lactams). -(SPRINGER, J.; JANSEN, T. P.; INGEMANN, S.; HIEMSTRA, H.; VAN MAARSEVEEN*, J. H.; Eur.