ChemInform Abstract: Low Catalyst Loadings for Ligand‐Free Copper(I)‐Oxide‐Catalyzed N‐Arylation of Methanesulfonamide in Water.

Tan, Bryan Yong-Hao; Teo, Yong‐Chua; Seow, Ai-Hua

doi:10.1002/chin.201448083

Cited by 1 publication

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“…Firstly, they use aromatic amines which are carcinogens 11 and secondly, they lead to impure products. Other important methods for the synthesis of N -arylsulfonamide derivatives is the reaction of sulfonamides as nucleophiles with some organic compounds such as halides 12 – 15 , alcohols 16 – 21 , aryl esters 22 – 24 and arylboronicacids 25 – 28 . In these methods although the problem of using aniline has been solved, but some disadvantages such as harsh reaction conditions, tedious workup, using metal catalysts, bases and/or ligands accompany these methods.…”

Section: Introductionmentioning

confidence: 99%

A tunable pair electrochemical strategy for the synthesis of new benzenesulfonamide derivatives

Mokhtari

Nematollahi

Salehzadeh

2019

Sci Rep

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A green, facile and tunable pair electrochemical process was developed for the synthesis of new benzenesulfonamide derivatives by using reductive controlled potential electrolysis of dinitrobenzene (DNB) in the presence of arylsulfinic acids (ASAs). In addition to the usual features associated with paired electrochemical methods, eg high energy efficient, this method has a tunable characteristic, so that, by adjusting the potential, different products can be synthesized. By applying the potential of −0.4 V vs. Ag/AgCl, N-hydroxy-N-(4-nitrophenyl)benzenesulfonamide derivatives are selectively formed, while, by applying the potential of −1.1 V vs. Ag/AgCl, the final products are N-(4-amino-3-(phenylsulfonyl)phenyl) benzenesulfonamide derivatives. This work beautifully shows the potential applications of the electrochemistry as a powerful tool for the synthesis of organic compounds.

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