ChemInform Abstract: Microwave and Conventional Techniques for the Synthesis of a Series of Pyrazolo[5,4‐d]pyrimidine Derivatives and Their Antimicrobial Screening.

Rana, P. B.; Patel, Jayesh; Mistry, B. D.; Desai, K. R.

doi:10.1002/chin.201012145

Cited by 2 publications

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“…[5][6] Pyrimidine derivatives possess very interesting pharmacological and biological properties and are reported to exhibit variety of biological activities like antibacterial, antifungal and anticonvulsant, analgesic, anti-inflammatory, antihelmentic, sedative, hypnotic, antispasmodic, 7-10 local anaesthetic Antitubercular, antihistaminic, antioxidant and anticancer activity. [11][12][13][14]…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization and Anti-Microbial Activity of Novel Pyramidine Derivatives

Kumar¹,

Sumanjali²,

Chandana³

et al. 2021

J. Drug Delivery Ther.

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Pyrimidine is a heterocyclic aromatic organic compound similar to benzene and pyridine, containing two nitrogen atoms at positions 1 and 3 of the six-member ring. Three nucleobases found in nucleic acids, cytosine (C), thymine (T), and uracil (U), are pyrimidine derivatives. A pyrimidine has many properties in common with pyridine, as the number of nitrogen atoms in the ring increases the ring pi electrons become less energetic and electrophilic aromatic substitution gets more difficult while nucleophilic aromatic substitution gets easier. Chalcones react with aminoguanidine to give intermediate compounds which on further reacts with substituted ketones to give Pyramidine derivatives. A total of 6 compounds were synthesized from one scheme and they were recrystallized by appropriate solvents. They were identified and characterized by various spectral methods. In the present study, all synthesized compounds tested for anti bacterial activity and anti-fungal activity. They shown significant activity when compared with standard drug Streptomycin and Miconazole respectively. Keywords: Pyramidines, Characterization, Streptomycin, Miconazole, Anti-microbial activity.

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Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization and Anti-Microbial Activity of Novel Pyramidine Derivatives

Kumar¹,

Sumanjali²,

Chandana³

et al. 2021

J. Drug Delivery Ther.

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“…Solvent-free reaction leads to a clean, eco-friendly and economic technology. Reactions on solid support without using solvent usually with close vessel in Synthos-3000, Anton Paar microwave reaction system is currently popular among the synthetic chemists to create eco-friendly atmosphere (Loupy, 2002;Rana et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Conventional and microwave techniques for synthesis and antimicrobial studies of novel 1-[2-(2-chloro(3-quinolyl))-5-(4-nitrophenyl)-(1,3,4-oxadiazolin-3-yl)]-3-(aryl)prop-2-en-1-ones

Desai

Dodiya

2011

Med Chem Res

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In this article, we have described the conventional and microwave method for the synthesis of 1-[2-(2-chloro(3-quinolyl))-5-(4-nitrophenyl)(1,3,4-oxadiazolin-3-yl)]-3-(aryl)prop-2-en-1-ones (4a-l). Through this method, we have achieved reduction in reaction time and better yield than the previously described conventional method. The application of microwave irradiation (MWI) is used for carrying out chemical transformations which are pollutionfree and eco-friendly. The structure of the compounds was characterized by spectral data. These compounds (4a-l) were evaluated for their in vitro antimicrobial screening on different strains of bacteria and fungi.

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ChemInform Abstract: Microwave and Conventional Techniques for the Synthesis of a Series of Pyrazolo[5,4‐d]pyrimidine Derivatives and Their Antimicrobial Screening.

Cited by 2 publications

References 0 publications

Synthesis, Characterization and Anti-Microbial Activity of Novel Pyramidine Derivatives

Synthesis, Characterization and Anti-Microbial Activity of Novel Pyramidine Derivatives

Conventional and microwave techniques for synthesis and antimicrobial studies of novel 1-[2-(2-chloro(3-quinolyl))-5-(4-nitrophenyl)-(1,3,4-oxadiazolin-3-yl)]-3-(aryl)prop-2-en-1-ones

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