ChemInform Abstract: Microwave‐Assisted Convenient Synthesis of α,β‐Unsaturated Esters and Ketones via Aldol‐Adduct Elimination.

Abstract

Microwave-Assisted Convenient Synthesis of α,β-Unsaturated Esters and Ketones via Aldol-Adduct Elimination. -Various fluorinated 3-oxo ester and 1,3-diketones are reacted with aldehydes (I) in the presence of piperidine to afford title compounds such as (III) and (V) (34 example). The reaction proceeds via formation of a primary aldol adduct and in situ stereoselective elimination of piperidinium trifluoroacetate. -(SUMAN, P.; RAO, R. N.; RAJU*, B. C.; Helv. Chim. Acta 96 (2013) 8, 1548-1559, http://dx.