ChemInform Abstract: Mitsunobu Type C—N Bond Formation with 4,7‐Dimethyl‐3,5,7‐hexahydro‐1,2,4,7‐tetrazocin‐3,8‐dione (DHTD), a New Cyclic Azodicarboxamide.

Abstract

Mitsunobu 5,2,4,, a New Cyclic Azodicarboxamide.-An efficient Mitsunobu type formation of C-N bonds between alcohols (I) and N-methyltosylamide, a typical N-nucleophile, is achieved in the presence of DHTD and tributylphosphine. Even the secondary alcohol (Id) gives good yields. -(TSUNODA, T.; KAWAMURA, Y.; UEMOTO, K.; ITO, S.; Heterocycles 47 (1998) 1, 177-179; Fac. Pharm. Sci.,