ChemInform Abstract: Monosaccharide as a Central Scaffold Toward the Construction of Salicylate‐Based Bidentate PTP1B Inhibitors via Click Chemistry.

Abstract

Monosaccharide as a Central Scaffold Toward the Construction of Salicylate--Based Bidentate PTP1B Inhibitors via ClickChemistry. -A series of bidentate triazolyl glucosides bearing two salicylic precursors on 2,6-, 3,4-, 4,6-, and 2,3-position of the central glucosyl scaffold is prepared via click chemistry as key step. An inhibitory assay leads to the identification of the free acid of derivative (III) as the most potent inhibitor of protein tyrosine phosphatase 1B with at least 3-fold enhanced inhibitory activity compared to the other triazolyl-glucosides. -(TANG*, Y.-H.; HU, M.; HE, X.-P.; FAHNBULLEH, S.; LI, C.; GAO, L.-X.; SHENG, L.; TANG, Y.; LI, J.; CHEN, G.-R.; Bull. Korean Chem.