ChemInform Abstract: N‐Aryl Cinnamides: A Novel Class of Rigid and Highly Potent Leukotriene B4 Receptor Antagonists.

Abstract

Several derivatives of the title compound (V) are found to be potent antagonists of the human neutrophil receptor. This series is unique among LTB4 antagonists due to its high degree of rigidity (no yields given). -(GREENSPAN, P. D.; MAIN, A. J.; BHAGWAT, S. S.; BARSKY, L. I.; DOTI, R. A.; ENGLE, A. R.; FREY, L. M.; ZHOU, H.; LIPSON, K. E.; CHIN, M. H.; JACKSON, R. H.; UZIEL-FUSI, S.; Bioorg. Med. Chem. Lett. 7 (1997) 7, 949-954; Arthritis Bone Metab. Res., Novartis Pharm. Corp., Summit, NJ 07901, USA; EN)