ChemInform Abstract: New Facile Synthesis of Dimethyl(phenyl)carbinol and Its Acetate.

Abstract

New Facile Synthesis of Dimethyl(phenyl)carbinol and Its Acetate. -The carbinols (II) and (IV), useful as aroma chemicals in perfumery and flavor industry, are prepared by nucleophilic substitution of the tertiary chloride (I) by Zn(OH)2 and Zn acetate under optimized conditions with suppressed formation of dimeric by-products. -(GURUDUTT, K. N.; RAO, L. J. M.; RAO, S.; SRINIVAS, P.; Indian J.

10.1007/s11178-008-2001-z

“…In [79] lithium in ethylenediamine was used for reduction of terminal epoxides to alcohols. It was shown in [140] that this reducing system is advantageous for reactions with sterically hampered tri-and tetrasubstituted oxiranes. Lithium in ethylenediamine proved to be a fairly convenient reducer in the series of epoxysteroids; 7α,8αand 9α,11α-epoxysteroids that were reluctant to react with lithium aluminum hydride were easily converted by this procedure into axial 8α-and 9α-alcohols.…”