ChemInform Abstract: Optimized Synthesis and Antimalarial Activity of 1,2‐Dioxane‐4‐carboxamides.

Abstract

Optimized Synthesis and Antimalarial Activity of 1,2-Dioxane-4-carboxamides. -A series of the title compounds is synthesized as exemplified by the presented synthesis of (IX). The compounds are tested for their antimalarial activity with compound (IXb) showing activity comparable to the natural product lead plakortin. -(LOMBARDO*, M.; et al.; Eur.