ChemInform Abstract: Partial Structures of the Fungal Toxin Aflatrem, Methyl‐Substituted 6, 8‐Dioxabicyclo(3.2.1)octan‐2‐ones Having Anticonvulsant Activity.

Abstract

Partial Structures of the Fungal Toxin Aflatrem, Methyl-Substituted 6, 8-Dioxabicyclo(3.2.1)octan-2-ones Having Anticonvulsant Activity. -The synthesis of a number of methyl-substituted 6,8-dioxabicyclooctanes (cf. (V), (VII)), substructures of the fungal toxin aflatrem (I), in racemic and enantiopure form is given. All of these compounds display anticonvulsant activity, whereat highest levels are observed for the (-)-enantiomer of (VIIa). -(TINAO-WOOLDRIDGE, L. V.; HSIANG, B. C. H.; LATIFI, T. N.; FERRENDELLI, J. A.; COVEY, D. F.; Bioorg. Med.