ChemInform Abstract: Pd‐Catalyzed Intramolecular Direct Arylations at High Temperature.

Abstract

Pyridazine derivatives R 0500Pd-Catalyzed Intramolecular Direct Arylations at High Temperature. -The microwave-assisted Pd-catalyzed high-temperature intramolecular arylation reaction proceeds smoothly at aromatic C-Br and activated azahetaromatic C-Cl bonds to afford a diversity of fused pyridazine or pyridine derivatives in good yields. Main features of the reaction are low catalyst loading (1mol% in most cases), short reaction times (10 -30 minutes) and wide applicability. -(FRANCK, P.; HOSTYN, S.; DAJKA-HALASZ, B.; POLONKA-BALINT, A.; MONSIEURS, K.; MATYUS, P.; MAES*, B. U. W.; Tetrahedron 64 (2008) 26, 6030-6037; Dep. Chem., Univ. Antwerp, B-2020 Antwerpen, Belg.; Eng.) -Mischke 42-144