ChemInform Abstract: Potent Antimalarial Activities of Polyether Antibiotic, X‐206.

Abstract

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Secondary metabolites from hypocrealean entomopathogenic fungi: novel bioactive compounds

“…128,129 However, compounds 131-134 did not show antimicrobial activities against Bacillus subtilis DSM10, Escherichia coli DSM498, Candida tenuis MUCL29892 and Mucor plumbeus MUCL49355, nor did they display cytotoxicity against KB-3-1 (human cervix carcinoma) and L929 (established mouse fibroblast) cells. 59 Five new cyclodepsipeptides, iso-isariin B (135) and D (136), desmethylisaridin E (137), desmethylisaridin C2 (138), and isaridin F ( 139), together with seven known cyclodepsipeptides, isaridin E (140) 130 131 Compound 139 features a rare α-N-methylbutyric acid constituent. Iso-isariin B (135) caused significant lethality against the insect pest Sitophilus spp.…”

“…Compound 154 also displayed antibacterial activities, just as its analogue fusidic acid. 136 Human African trypanosomiasis, also known as sleeping sickness, is a potentially fatal parasitic disease transmitted by the bite of the tsetse fly that plagues many regions of Africa.…”