ChemInform Abstract: POTENTIAL BROAD SPECTRUM ANTHELMINTICS. PART 5: DESIGN, SYNTHESIS AND SPECTRAL STUDY OF 2‐ACETYLAMINO‐5‐ARYLTHIAZOLO(2,3‐B)‐1,3,4‐THIADIAZOL‐4‐IUM PERCHLORATES

Abstract

Das Thiadiazol (I) reagiert mit den Phenacylbromiden (II) zu den Thiadiazol‐phenacylsulfiden (III); diese gehen mit Polyphosphorsäure in die heterocyclischen Ammoniumsalze (IV) über.

Synthesis, spectroscopic and crystal structure analysis of a compound with pharmocophoric substituent: 2-cyclohexyl-6-(2-oxo-2H-chromen-3-yl)- imidazo[2,1-b][1,3,4]thiadiazole-5-carbaldehyde

“…The reaction of 2-amino-5-cyclohexyl-1,3,4-thiadiazole 10 (1) and 3-bromoacetyl coumarin 11 (2) in boiling ethanol afforded 3-(2-cyclohexylimidazo[2,1-b]- [1,3,4]thiadiazol-6-yl)-2H-chromen-2-one (3) as hydrobromide salt, which was neutralized by sodium carbonate solution to get the free base. It was subjected to Vilsmeir Haack reaction to yield…”

“…[2,1-b] [1,3,4] thiadiazole-5-carbaldehyde (4). Vilsmeier-Haack reagent was obtained by adding POCl 3 (3 ml) in DMF (20 ml) at 0 • C, with stirring.…”

“…Imidazo [2,1-b] [1,3,4] thiadiazole (IT) deriva tives with pharmacophoric substituents have promising biological and pharmacological activities. The title compound is one of such derivatives, with a coumarin molecule linked to the IT ring system.…”

“…(2) Department of Chemistry, Karnatak University, Dharwad 580003, India. * To whom correspondence should be addressed; e-mail: noorsb@ rediffmail.com reported to possess diverse pharmacological properties viz., antibacterial, 2 analgesic 3 and anthelmintic 4 activities. Coumarin derivatives are also found in varieties of natural products 5 and many of them display pharmacological properties.…”

“…The title compound was synthesized using Vilsmeier-Haack reagent which was made to react with the prepared 3-(2-cyclohexylimidazo[2,1-b] [1,3,4]thiadiazol-6-yl)-2H-chromen-2-one. This was followed by measurement of analytical data relating to the compound.…”