ChemInform Abstract: Rapid, Quantitative, Solvent‐Free Synthesis of Medium‐Ring Diaza Heterocycles from Diketene—Acetone Adduct and Diamines.

Abstract

Rapid, Quantitative, Solvent-Free Synthesis of Medium-Ring Diaza Heterocycles from Diketene-Acetone Adduct and Diamines. -The remarkably efficient synthesis of biologically relevant diazepines, diazocines, and diazonines is also performed using conventional heating instead of microwave irradiation with virtually identical product yields after slightly longer reaction times. -(MORRISON, C. S.; LAMPE, J. B.; KOLODZIEJCZYK, T. C.; CAVAZOS, R. J.; PETROS*, R. A.; Tetrahedron Lett. 55 (2014) 48, 6547-6549, http://dx.