ChemInform Abstract: Readily Available Chiral Phosphine—Aminophosphine Ligands Derived from 1‐Phenylethylamine for Rh‐Catalyzed Enantioselective Hydrogenations.

Abstract

Readily Available Chiral Phosphine-Aminophosphine Ligands Derived from 1-Phenylethylamine for Rh-Catalyzed Enantioselective Hydrogenations. -Among the novel phosphineaminophosphine derivatives prepared, effective ligands are identified for the Rh-catalyzed asymmetric hydrogenation of enamides (II), Z-β-dehydroamino acid esters (VI), and itaconate (IX). Optimization of the ligand structure is given for each type of substrate. The ligands are not suitable for α-dehydroamino acid esters like (XI). -(ZHOU, X.-M.; HUANG, J.-D.; LUO, L.-B.; ZHANG, C.-L.; ZHENG, Z.; HU*, X.-P.; Tetrahedron: Asymmetry 21 (2010) 4, 420-424,