ChemInform Abstract: Reduction of the Pyrimidine Ring: Regio‐ and Stereoselective Synthesis of 1,3‐Diamine Derivatives.

Abstract

Reduction of the Pyrimidine Ring: Regio-and Stereoselective Synthesis of 1,3-Diamine Derivatives.-The N,N'-disubstituted 1,3-diamines (II) are produced by stereoselective reductive cleavage of the 1-butyl-1,2-dihydropyrimidines (I) which are prepared according to known procedures.The method is also applied to the fused pyrimidines (III), yielding the diamines (IV) or the octahydropyrrolo(1,2-a)pyrimidines ( V) depending on the reduction conditions employed.-(BARLUENGA, J.; TOMAS, M.; KOUZNETSOV, V.; JARDON, J.; RUBIO, E.; Synlett (1991) 11, 821-823; Dep. Quim. Organomet., Fac. Quim., Univ., 33071 Oviedo, Spain; EN)