ChemInform Abstract: Regioselective Nucleophilic Addition of 3‐Aryl‐5‐difluoromethyl‐isoxazoles to Aldehydes.

Abstract

Regioselective Nucleophilic Addition of 3-Aryl-5-difluoromethyl-isoxazoles to Aldehydes. -The direction of the title reaction depends on the base employed and provides regioselective access to side chain alkylated products (IV) or ring-alkylated products (V). -(YANG, X.; FANG*, X.; ZHANG, D.; YU, Y.; ZHANG, Z.; WU, F.; J. Fluorine Chem. 145 (2013) 1-7, http://dx.