ChemInform Abstract: Regioselective Synthesis and Evaluation of 3‐Alkylidene‐1,3‐dihydroisobenzofurans as Potential Antidepressant Agents.

Abstract

Phthalanes (II) and (IV) are obtained regio‐, stereo‐, and chemoselectively by Cu(II)‐catalyzed cycloisomerization of 2‐ethynylbenzyl alcohols.

Time and Temperature Dependent Palladium-Catalyzed Stereo- and Regioselective Alkoxy-arylation of Triple Bonds: Synthesis of (E)/(Z)-1,1-Disubstituted-3-(1-Phenylalkylidene)-1,3-dihydroisobenzofurans

“…26 Zhu and co-workers described the synthesis of 1,3-dihydroisobenzofurans using copper catalysis (Figure 1c). 11 In 2012, Perumal et al reported the synthesis of 1,3-dihydroisobenzofurans and their antidepressant activity (Figure 1d). 11 5-exo-dig cyclization (Figure 1e).…”

“…1 Particularly, 1,3-dihydroisobenzofuran (phthalan) derivatives are known to exhibit a wide variety of drug-like properties, 2−5 such as potent antioxidant, 6 antidepressant, antihistaminic, 7 anti-inflammatories, 8,9 and antifungal properties, etc. 10,11 Therefore, the synthesis of dihydroisobenzofurans has drawn considerable attention from the synthetic community. Generally, the intramolecular cyclizations of 2-alkynyl phenyl ketones have been well explored to accomplish isobenzofurans, 12 isocoumarins, 13 isoindoline-1-ones, 14 cyclic imidates, 15 and dihydroisobenzofurans.…”

“…11 In 2012, Perumal et al reported the synthesis of 1,3-dihydroisobenzofurans and their antidepressant activity (Figure 1d). 11 5-exo-dig cyclization (Figure 1e). 27 Intramolecular hydroalkoxylation of 2-(1-alkynyl) tertiary benzylic alcohols was reported by Yu et al (Figure 1f).…”