ChemInform Abstract: Review on Synthesis of Bioactive Pyrazoline Derivatives

Sharma, Sunita; Kaur, Sandeep; Bansal, Tania; Gaba, Jyoti

doi:10.1002/chin.201504266

Cited by 16 publications

(20 citation statements)

References 1 publication

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“…Studies have shown that azachalcones possess anti-bacterial, anti-inflammatory, and anti-cancer properties [ 28 , 29 , 30 , 31 ]. Azachalcones also served as precursors for synthesis of pyrazolines and pyrazoles [ 32 ].…”

Section: Introductionmentioning

confidence: 99%

Halo-Substituted Chalcones and Azachalcones Inhibited Lipopolysaccharited-Stimulated Pro-Inflammatory Responses through the TLR4-Mediated Pathway

Shih

Liu

et al. 2018

Molecules

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A series of B-ring, halo-substituted chalcones and azachalcones were synthesized to evaluate and compare their anti-inflammatory activity. Mouse BALB/c macrophage RAW 264.7 were pre-treated with 10 μg/mL of each compound for one hour before induction of inflammation by lipopolysaccharide (1 μg/mL) for 6 h. Some halo-chalcones and -azachalcones suppressed expression of pro-inflammatory factors toll-like receptor 4 (TLR4), IκB-α, transcription factor p65, interleukine 1β (IL-1β), IL-6, tumor necrosis factor α (TNF-α), and cyclooxygenase 2 (COX-2). The present results showed that the synthetic halo-azachalcones exhibited more significant inhibition than halo-chalcones. Therefore, the nitrogen atom in this series of azachalcones must play a more crucial role than the corresponding C-2 hydroxyl group of chalcones in biological activity. Our findings will lay the background for the future development of anti-inflammatory nutraceuticals.

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Section: Introductionmentioning

confidence: 99%

Halo-Substituted Chalcones and Azachalcones Inhibited Lipopolysaccharited-Stimulated Pro-Inflammatory Responses through the TLR4-Mediated Pathway

Shih

Liu

et al. 2018

Molecules

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“…The properties and applications of pyrazoline and their analogues are numerous and known, not only in the biological and medical field, [1][2][3][4] but also for their potential and practical applications as materials with luminescent and nonlinear optical properties. [5][6][7][8] The building of these N-heterocycles systems, from simple reactions, using small molecules and compatible with multicomponent, regioselective, eco-friendly and efficient synthetic procedures, which include variations to conventional methods, allows to incorporate specific structural characteristics.…”

Section: Introductionmentioning

confidence: 99%

Syntheses, Experimental and Theoretical Studies on Absorption/Emission Properties of Pyrazoline-Containing Aryl/Methoxynaphthyl Substituents

Trilleras¹,

González-López²,

León-Jaramillo³

et al. 2017

J. Braz. Chem. Soc.

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5-Aryl-3-(2-methoxynaphthalen-6-yl)-1-phenylpyrazoline derivatives were synthesized starting from (E)-1-(3-aryl)-(2-methoxynaphthalen-6-yl)-prop-2-en-1-one and phenylhydrazine. The compounds were characterized by 1 H and 13 C nuclear magnetic resonance (NMR), elemental analyses and mass spectrometry. Some compounds showed promising luminescence properties in solution and in solid state; the absorption and emission characteristics were measured and the fluorescence quantum yield of two of the derivatives [4,5-dihydro-3-(2-methoxynaphthalen-6-yl)-5-(3,4,5-trimethoxyphenyl)-1-phenyl-1H-pyrazoline and 5-(4-chlorophenyl)-4,5-dihydro-3-(2-methoxynaphthalen-6-yl)-1-phenyl-1H-pyrazoline] were found to have excellent values compared to rhodamine B standard. Theoretical calculations at time-dependent density functional theory (TD-DFT) level are in agreement with the experimental measurements and are helpful to explain the electronic behavior.

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“…Their usage in the treatment is attributed to their inherent toxicity to various pathogens 4 . Pyridine derivatives are an interesting class of heterocycles due to their synthetic versatility and effective biological activities such as antimicrobial 5 7 , anticancer 8 , anticonvulsant 9 , antiviral 10 , anti-HlV 11 , antimycobacterial and antifungal activities 12 .…”

Section: Introductionmentioning

confidence: 99%

Potential Biosignificant Interest and Surface Activity of Efficient Heterocyclic Derivatives

El‐Sayed

Althagafi

2016

J. Oleo Sci.

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ChemInform Abstract: Review on Synthesis of Bioactive Pyrazoline Derivatives

Abstract: Review: 43 refs.

Cited by 16 publications

References 1 publication

Halo-Substituted Chalcones and Azachalcones Inhibited Lipopolysaccharited-Stimulated Pro-Inflammatory Responses through the TLR4-Mediated Pathway

Halo-Substituted Chalcones and Azachalcones Inhibited Lipopolysaccharited-Stimulated Pro-Inflammatory Responses through the TLR4-Mediated Pathway

Syntheses, Experimental and Theoretical Studies on Absorption/Emission Properties of Pyrazoline-Containing Aryl/Methoxynaphthyl Substituents

Potential Biosignificant Interest and Surface Activity of Efficient Heterocyclic Derivatives

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