ChemInform Abstract: SOFT DRUGS. 3. A NEW CLASS OF ANTICHOLINERGIC AGENTS

Abstract

Es werden quaternäre Ammoniumester (I)‐(III) in literaturbekannter Weise dargestellt, von denen einige bei verkürzter Wirkungsdauer eine fast Zehnfache Acetylcholin‐Antagonist‐Aktivität verglichen mit Atrogin besitzen.

Receptor binding studies of soft anticholinergic agents

“…Soft anticholinergics were intended for topical application, for example, to be used as antiperspirants (13) or as mydriatic agents (14,15). By incorporating an adequate metabolically labile moiety into their structure, they can be potent and locally active as anticholinergic agents, but with only minimal systemic anticholinergic effects due to their rapid metabolism in the systemic circulation.…”