ChemInform Abstract: Stereoselective Reactions. Part 23. Design, Synthesis, and Structure‐ Cytotoxicity Relationships of Aza‐Steganes.

Abstract

Stereoselective Reactions. Part 23. Design, Synthesis, and Structure-Cytotoxicity Relationships of Aza-Steganes. -With a view to obtaining new antitumor agents the title compounds (V)-( VIII) are prepared. The debromobenzylation of compound (IVb) proceeds analogously to that of (IVa). The azaisopicrostegane (VIII) is prepared in the same way as (IV). Compounds (V) and (VIII) show higher cytotoxicities than (VI) and (VII). The X-ray analysis of (VIII) shows that the dibenzocyclooctadiene skeleton adopts a boat-chair conformation which is necessary for the observed biological activity. -(KUB-OTA, Y.; KAWASAKI, H.; TOMIOKA, K.; KOGA, K.; Tetrahedron 49 (1993) 15, 3081-3090; Inst. Sci. Ind. Res.,