ChemInform Abstract: STUDIES IN THE FIELD OF PYRIDAZINE COMPOUNDS, III (1). HYPOTENSIVE 3‐(1‐PYRAZOLYL) PYRIDAZINE DERIVATIVES

Abstract

Zahlreiche 3‐[Pyrazolyl‐( 1 )]‐pyridazin‐Derivate wurden nach Literaturmethoden synthetisiert und in Tierversuchen (Katzen, Ratten) auf ihre hxgotensive und/oder inhibitorische Aktivität auf den PG‐Metabolismus getestet.

Amide Derivatives of [6‐(5‐Methyl‐3‐phenylpyrazole‐1‐yl)‐3(2H)‐pyridazinone‐2‐yl]acetic Acids as Potential Analgesic and Anti‐Inflammatory Compounds

“…In the synthesis of the amide derivatives (6 a-m), commercially available 3,6-dichloropyridazine was used as the starting material, and 6-(5-methyl-3-phenylpyrazole-1-yl)-3(2H)-pyridazinone (3) were prepared by adapted procedures according to the previously published methods [20,21]. 3 was then treated with ethyl bromoacetate to prepare the ethyl [6-(5-methyl-3-phenylpyrazole-1-yl)-3(2H)-pyridazinone-2-yl]acetate (4) which was subsequently acid-hydrolysed to obtain [6-(5-methyl-3-phenylpyrazole-1-yl)-3(2H)-pyridazinone-2-yl]acetic acid (5).…”

Synthesis and biological properties of novel 3-(pyrazol-1-yl)-6-oxopyridazine derivatives

“…Pyrazolylpyridazines, obtained by cyclization of 3-hydrazino-pyridazines, have hypotensive, anti-inflammatory, antibacterial, and antioxidant activity. [10][11][12][13] However, it is surprising that in the literature there are practically no data on pesticides or plant growth stimulants based on non-fused heterocyclic system derivatives with a combination of pyrazolylpyridazine fragment and azoles in the structure. At the same time, the increasing awareness of environmental requirements, as well as the fact that harmful organisms can acquire resistance to chemical means of plant protection, make it necessary to replenish the pesticide arsenal with new and more environmentally friendly chemicals that have different mechanisms of action.…”

1,3‐dipolar cycloaddition reaction: Synthesis and configuration of norcantharidin derivatives of substituted aromatic amine

“…In this context and with our sustained interest in the 1,3-dipolar cycloaddition of nitrile oxide, we successfully design and efficiently synthesize the norcantharidin isoxazoline adducts. Such types of compounds with potential versatile activities may be of interest in chemistry, biochemistry and pharmacology [4][5][6]. The synthesis routes of the compounds mentioned above are outlined in Scheme 1.…”